2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W016798
    (S)-2-acetamido-4-amino-4-oxobutanoic acid 4033-40-3 98.0%
    (S)-2-acetamido-4-amino-4-oxobutanoic acid is a metabolite. (S)-2-acetamido-4-amino-4-oxobutanoic acid can be used in the research of decompensated liver cirrhosis.
    (S)-2-acetamido-4-amino-4-oxobutanoic acid
  • HY-W019704
    N-Acetyl-DL-methionine 1115-47-5
    N-Acetyl-DL-methionine is an endogenous metabolite.
    N-Acetyl-DL-methionine
  • HY-W030796
    Lactisole free acid 13794-15-5 99.75%
    Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets.
    Lactisole free acid
  • HY-W040948
    2-Ethylpyrazine 13925-00-3 99.99%
    2-Ethylpyrazine is an endogenous metabolite.
    2-Ethylpyrazine
  • HY-W045990
    2,7-Dimethylnaphthalene 582-16-1 ≥98.0%
    2,7-Dimethylnaphthalene is a selective cytochrome P450 1A2 (CYP1A2) enzyme inhibitor with an IC50 of 65 μM. 2,7-Dimethylnaphthalene can be used for the research of metabolic disease.
    2,7-Dimethylnaphthalene
  • HY-W052011
    Ruzinurad 1638327-48-6 99.26%
    Ruzinurad (HR011303) is a highly selective URATl inhibitor (WO2020088641, compound I). Ruzinurad can be used in the study of hyperuricemia.
    Ruzinurad
  • HY-W102510
    Gallacetophenone 528-21-2 99.97%
    Gallacetophenone is an inhibitor of α-glucosidase with an IC50 value of 408.6 μM. When combined with 1-Deoxynojirimycin (HY-14860), Gallacetophenone exhibits synergistic inhibitory effects on mammalian α-glucosidase at high concentrations. Gallacetophenone can be used in the study of diseases such as type 2 diabetes.
    Gallacetophenone
  • HY-W106057
    11β-HSD1-IN-7 728-86-9 99.73%
    11β-HSD1-IN-7 (compound c10a) is a 11β HSD1 inhibitor with an IC50 value of 1.9 μM for human 11β HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline.
    11β-HSD1-IN-7
  • HY-W127350
    Cholesterol Pelargonate 1182-66-7
    Cholesterol Pelargonate, a Cholesterol derivative, can be used as a triggered release liposome tested.
    Cholesterol Pelargonate
  • HY-W127841
    Citric acid-2,4-13C2 121633-50-9 98.00%
    Citric acid-2,4-13C2 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid-2,4-13C2
  • HY-W130074
    α-Pinene oxide 1686-14-2
    α-Pinene oxide is a type of monoterpene epoxidation intermediate. α-Pinene oxide is produced via the cytochrome P-450-mediated oxidation pathway in Dendroctonus terebrans body microsomes and rat liver microsomes, and can be further converted into alcohols, ketones and insect pheromone derivatives. α-Pinene oxide can generate the perfume intermediate myrtenal. α-Pinene oxide is used in studies related to terpenoid metabolism and perfume synthesis.
    α-Pinene oxide
  • HY-W144096
    Methyl 2,4,6-trihydroxybenzoate 3147-39-5 98.20%
    Methyl 2,4,6-trihydroxybenzoate is a metabolite of 2,4,6-trihydroxybenzoate and exhibits properties as an antioxidant, lipid lowering and anticancer activities.
    Methyl 2,4,6-trihydroxybenzoate
  • HY-W212029
    D-Ala-Leu 67113-60-4 99.08%
    D-Ala-Leu (D-Alanyl-L-leucine; H-D-Ala-Leu-OH) is a dipeptide that acts as a source donor of L-Leucine (HY-N0486).
    D-Ala-Leu
  • HY-W337897
    Tetradecyl-β-D-maltoside 18449-82-6 99.96%
    Tetradecyl-β-D-maltoside is an absorption enhancer which can increase the nasal absorption of regular human insulin or the fast acting insulin analog lyspro-insulin.
    Tetradecyl-β-D-maltoside
  • HY-W343750
    [Tyr4]-Bombesin 67338-70-9 98.66%
    [Tyr4]-Bombesin is a Bombesin analogue, is a ligand of gastrin-releasing peptide receptor (GRPR).
    [Tyr4]-Bombesin
  • HY-W414823
    24,25-Epoxycholesterol 72542-49-5 99.80%
    24,25-Epoxycholesterol is an oxysterol agonist of the liver X receptor that can inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in liver cells. 24,25-Epoxycholesterol regulates cholesterol metabolism in the liver.
    24,25-Epoxycholesterol
  • HY-W587537
    Deoxycholic acid 3-O-β-D-glucuronide disodium 59274-67-8 99.59%
    Deoxycholic Acid 3-O-beta-D-Glucuronide disodium salt is a bile acid receptor (FXR) agonist.
    Deoxycholic acid 3-O-β-D-glucuronide disodium
  • HY-W743862
    Dihydro T-MAS 5241-24-7 99.86%
    Demethyldihydrolanosterol belongs to the class of sterols and is a derivative of lanosterol. Demethyldihydrolanosterol can be studied in research on cholesterol biosynthesis and the development of pharmaceuticals targeting cholesterol-related pathways.
    Dihydro T-MAS
  • HY-W753593
    N4-Acetylcytidine-13C5
    N4-Acetylcytidine-13C5 is the 13C-labeled N4-Acetylcytidine (HY-W019670). N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity.
    N4-Acetylcytidine-13C5
  • HY-W760733
    2,4-Decadienal 2363-88-4
    2,4-Decadienal is a toxic aldehyde produced by the oxidation of linoleic acid-rich oils. 2,4-decadienal can be used as an alternative oxidation indicator for linoleic acid-rich oils.
    2,4-Decadienal
Cat. No. Product Name / Synonyms Application Reactivity